Women with painful urethral opening during urination consider urethral infection. Because the female urethra is relatively short and the angle is relatively value straight, it is easy to occur urethral infection. Treatment: 1. Perform routine urine examination, if a large number of white blood cells are seen in the routine urine, the diagnosis can be confirmed. 2. Drink more water appropriately, the amount of water should be kept above 1000-1500ml daily. 3. Take 1 tablet of ciprofloxacin orally 3 times a day or 1 capsule of levofloxacin orally 3 times a day for 7 days. 4. Take 1 tablet of sodium bicarbonate orally 3 times a day for 7 days. 5.If the symptoms do not improve after using the above drugs for more than 3 days, it is recommended to consult a doctor to confirm the diagnosis and adjust the treatment to exclude stones or other systemic diseases such as tumors. 6.If there is a history of chills, fever or back pain during treatment, drug resistance and upper urinary tract infection caused by bacterial transfer to the upper urinary tract are considered, it is recommended to consult a doctor to adjust the treatment in time.