If the condition requires, celiac patients can usually take orlistat under the guidance of a doctor, but orlistat does not treat celiac disease. Orlistat is a lipase inhibitor that can reduce weight by inhibiting fat absorption in the intestines, and is commonly used clinically in the treatment of obesity. Common side effects of orlistat include abdominal pain, diarrhea, liver function impairment, urinary tract infection, headache, edema, and menstrual disorders. It is contraindicated in patients who are allergic to the drug, chronic malabsorption syndrome, and cholestasis. In addition, patients should minimize the intake of food with high fat content when taking this product. It is recommended that patients with celiac disease with obesity go to the regular hospital in time, after clarifying the cause of the disease, targeted treatment under the guidance of the doctor, in order to reduce the adverse effects of the disease.