Lung cancer metastasis to the brain will cause the patient’s brain tissue or nervous system to be compressed, and the patient may have the manifestation of headache all the time. For headache caused by lung cancer brain metastasis, medication and radiotherapy are needed to treat it. Lung cancer metastasis to brain tissues will cause tumor in brain, and as the tumor volume increases, it is easy to press on brain tissues, and patients will have manifestations such as continuous severe pain, projectile vomiting, optic nerve disk edema, etc., and the headache needs to be relieved after brain tumor is removed. In addition, brain metastasis of lung cancer will also compress or infiltrate the nervous system of the brain, and patients will also have headache all the time. Lung cancer metastasis to the brain causing headache needs to be treated with molecular targeting drugs such as gefitinib, bevacizumab and other chemotherapeutic drugs such as irinotecan, etoposide and other chemotherapeutic drugs under the guidance of doctor. In addition, patients need to take radiation irradiation treatment. Lung cancer metastasized to the brain may have the symptom of headache all the time, and it is suggested that patients should seek medical treatment in time, and they can choose targeted measures for treatment under doctors’ guidance.