The main component of the closed needle is glucocorticoid hormone, so the side effects caused by the closed needle are mainly adverse reactions to hormones, which can include local side effects and systemic side effects. General few closed needles tend to have small side effects, but if the use of more frequent, the total amount of larger side effects may occur, as follows: 1, local side effects: such as the long-term use of closed needles in a joint or a local skin, hormones can cause local skin atrophy, including subcutaneous fat will also be atrophied, resulting in the formation of local depression. Sometimes the surface of the skin color will appear hypopigmentation, if repeated local injections can induce infection. In addition, if the tendon site long-term injection of closed needles, can lead to tendon atrophy, and even rupture; 2, systemic side effects: if the closed needle use more, systemic absorption, can produce systemic adverse reactions. Such as osteoporosis, femoral head necrosis, hypertension, hyperglycemia, or lead to aggravation of gastrointestinal ulcers, bleeding, perforation, etc.. Therefore, there are strict indications for the use of closed needles, and should not be used at will.