The efficacy of closed injection usually lasts for about a week. Closed injection is mainly for local pain symptoms caused by local muscle, tendon, ligament and fascia strain and aseptic inflammation, which can play a good role in relieving. Closed injection mainly contains lidocaine injection, tretinoin injection, and methylcobalamin injection, vitamin B12 injection, etc.. These drugs need to be proportioned according to the specific pain area of the patient, and the injection should be administered locally after proportioning in a certain amount. After the injection, activities must be restricted for three days to prevent strenuous activities of the limbs and joints to promote the absorption of local drugs. When the local strenuous activity will lead to local edema, swelling and pain symptoms aggravated, so must limit the strenuous activity. Sterile gauze should be covered after sealing the needle to prevent local infection.