The baby’s sleeplessness with crying at night may be caused by environmental factors, gastrointestinal discomfort, lack of vitamin D or calcium and other factors, according to the specific circumstances to take to improve the sleep environment, take probiotics, vitamin D and calcium supplementation and other methods of treatment. 1. Environmental factors: it may be due to the sleeping environment is not conducive to sleep, such as the environment is noisy, not quiet, may also be due to the light is too strong, or the surrounding environment is too hot, etc., parents should adjust the indoor temperature and humidity in a timely manner, dimming the light, and to keep the room quiet and comfortable. 2. Gastrointestinal discomfort: the baby’s digestive system is immature, if not fed properly can easily lead to indigestion, bloating, stomach discomfort, which leads to the baby crying, sleep is not solid. You can take oral intestinal probiotics to regulate intestinal flora, or take pediatric chemo cum oral solution to relieve discomfort. 3. Lack of vitamin D or calcium: If the lack of vitamin D will lead to a lack of calcium in the body, nerve excitability increases, which leads to difficulty in falling asleep, irritability, hyperactivity, and even fall asleep always wake up frequently, appearing to cry more than the phenomenon. Vitamin D and calcium supplementation should be prescribed by the doctor to improve the phenomenon of sleeplessness and crying. In addition to the above factors, other factors cannot be ruled out. It is recommended to go to the hospital as soon as possible for examination, and give targeted treatment after the doctor clarifies the cause of the disease.