Long-term oxygen therapy for chronic obstructive pulmonary disease such as 24-hour oxygen can increase the partial pressure of blood oxygen in severe patients, which is beneficial to patients. It can also be combined with other medications. Standard long-term home oxygen therapy for patients with chronic obstructive pulmonary disease should be oxygenated for more than 15 hours per day to improve the patient’s oxygen saturation. At the same time, the oxygen flow is controlled at 1~2L/min, and the concentration of inspired oxygen is less than 30% to prevent inhibition of respiration, so 24 hours of oxygen inhalation is beneficial to patients with chronic obstructive pulmonary disease. Patients with chronic obstructive pulmonary disease can also be given appropriate medication for symptoms. For patients with phlegm that cannot be easily coughed up, expectorants such as Ambroxol hydrochloride can be used to relieve coughing and resolve phlegm. If there are wheezing symptoms, bronchodilators such as terbutaline, aminophylline and ipratropium bromide can be used to relieve shortness of breath. For patients with acute exacerbations, glucocorticosteroids such as methylprednisolone can be given if necessary. For patients with chronic obstructive pulmonary disease, oxygen therapy and medication should be used properly under the guidance of a doctor to avoid delaying the condition.