At present, the clinical treatment for sclerosing cholangitis includes drug treatment, surgical treatment and endoscopic treatment. 1. Drug treatment: some immunosuppressants such as glucocorticoids can be taken under doctor’s guidance, which can help to reduce the inflammatory symptoms of cholangitis and reduce the necrotic liver cells, and some choleretic drugs and preventive use of antibiotics can also be added. 2. Surgery: common surgical treatments include biliary drainage, colectomy (when patients are combined with ulcerative colitis at the same time), liver transplantation, etc. Biliary drainage can decompress the bile ducts and alleviate the obstruction symptoms of the patients, but it has a high recurrence rate and needs to be drained several times. 3. Endoscopic treatment: endoscopic treatment can take out the stones and relieve the symptoms of jaundice, which can effectively relieve the symptoms and reduce the obstruction. Patients with sclerosing cholangitis need to complete the relevant examinations under the guidance of the doctor, to carry out individualized treatment plans, and follow the doctor’s instructions.