Kidney transplantation is the best treatment for end-stage renal disease, replacing the kidney with a new one that has completely failed. Oral infections after kidney transplantation may be caused by immunocompromise, which can be treated by drugs such as anti-lymphocyte globulin, moromona-CD3, and adrenal cortical steroids. 1. Anti-lymphocyte globulin: It is a polyclonal serum with the ability to remove T and B lymphocytes. In clinical practice, it is commonly used to induce immunosuppression. 2. Moromona-CD3: is a murine IgG2 immunoglobulin. It inhibits T-lymphocyte activity and promotes the production and expression of a variety of cytokines. 3. adrenocortical steroids: a broad spectrum of anti-inflammatory and immunosuppressive agents that are used in combination with calcitonin, such as prednisone and methylprednisolone, in the early period after renal transplantation. Therefore, patients with oral infections after renal transplantation should go to the hospital as soon as possible, under the guidance of the doctor for standardized treatment, and the use of drugs need to follow the doctor’s instructions.