High leucine transpeptidase is mostly associated with liver diseases, such as viral hepatitis, cirrhosis, hepatocellular carcinoma and so on. Because the liver is the main site of leucine transpeptidase conversion and decomposition, liver disease changes will lead to damage to the active cells of the liver, thus affecting its normal circulation and metabolic function. Some of the unconverted leucine transpeptidase will enter the human blood system and eventually cause high levels in the serum test. In addition, leucine transpeptidase is also widely found in the pancreas, gallbladder, small intestine and other tissues, and pathological changes in these organs and tissues may also cause high levels of leucine transpeptidase. The common types of disease include pancreatitis, bile duct blockage, small intestine fibroids, etc. The exact cause of the disease needs to be confirmed after more detailed examination.