Lymphoma is a systemic disease, belonging to malignant tumor of hematopoietic system. Generally, b-cell lymphoma belongs to a large group of lymphomas, among which diffuse large b-cell lymphoma is more common, and the treatment effect is relatively good. The main treatment is combination chemotherapy, mainly with CHOP regimen chemotherapy, cyclophosphamide plus adriamycin and four drugs like oral prednisone plus vincristine. Generally speaking, after the initial treatment, the lymphoma treatment effect is very good, the lumps may shrink or disappear, but there is a possibility of relapse later, so it needs more courses of chemotherapy, it may have to be 8-10 times or more. In addition, some b-cell lymphoma can be combined with the targeted drug Merova, such as immunohistochemistry CD20 positive, combined with Merova treatment, the effect is a little better.