Ibuprofen doesn’t work for a toothache all night long, it is recommended to go to the stomatology department in time for treatment, different causes of toothache and take different measures, it may need to open the pulp and drain, peri-coronary rinsing and medication, incision and drainage of abscesses or extraction of the affected tooth. A toothache that lasts all night may be caused by pulpitis, which should be treated by drilling the tooth to open the pulp cavity and release the pressure caused by congestion in the pulp cavity, and the pain can be relieved after adequate drainage. The pain caused by peri-coronary abscess can go to the dentist for peri-coronary irrigation, rinse out the bacteria in the blind pocket of the gums, and then apply iodine glycerin and other drugs locally, which is prohibited for those who are allergic to iodine. For pain caused by apical or periodontal abscess, the abscess can be incised and drainage strips can be placed to drain out the pus if necessary. If the tooth is fractured, the tooth can be extracted to relieve the pain. Ibuprofen for toothache does not work should go to the regular hospital in time.