Thrombolysis is only effective in patients with acute ST-segment elevation myocardial infarction and is performed within the time window of thrombolytic therapy. In other patients with coronary artery disease, such as stable angina, unstable angina, and non-ST-segment elevation myocardial infarction, thrombolysis is not effective, but may have adverse effects. It can restore coronary artery blood flow, save the myocardium on the verge of necrosis, reduce the area of myocardial necrosis, protect and maintain the function of the heart, and improve the prognosis of patients with acute ST-segment elevation myocardial infarction. Thrombolysis is a reperfusion therapy, and it can be used as an alternative to reperfusion therapy when intervention is not available.