Take acute myocardial infarction as an example to explain the indications and contraindications of thrombolytic therapy referring to intravenous thrombolysis. First, the indications for thrombolysis in acute myocardial infarction: first, persistent chest pain greater than or equal to half an hour, and the symptoms are not relieved by nitroglycerin. Second, two or more adjacent leads ST segment elevation greater than 0.1mV in the limb lead, in the chest lead elevation greater than 0.6mV. third, the onset of ≤ 6 hours, if the onset of 6-12 hours, but still have this persistent ischemic attack, can also be used thrombolysis, in addition to the age of ≤ 70 years. Contraindications to thrombolysis: First, within 2 weeks, there is obvious active bleeding, such as internal organ surgery or cardiopulmonary resuscitation, and thrombolysis is not suitable. Second, blood pressure ≥ 160 mmHg, 100 mmHg. Third, a high suspicion of a coarctation aneurysm. Fourth, there is a history of cerebral hemorrhage or subarachnoid hemorrhage, within six months. Fifth, there is a hemorrhagic retinopathy. Sixth, there is a suspicion of hematologic disorders, which are all contraindications to thrombolysis.