Clarithromycin and levofloxacin hydrochloride are not antibiotics, as to which drug is better can not be generalized, need to be combined with the actual condition of the individual to choose the most appropriate drug. Clarithromycin is a macrolide antibiotic, can play a good inhibitory effect on gram-positive bacteria, some gram-negative bacteria, mycoplasma as well as some anaerobic bacteria. Levofloxacin hydrochloride, on the other hand, belongs to the quinolone class of antibiotics, and has antimicrobial effects against a wide range of gram-positive aerobic bacteria and gram-negative aerobic bacteria, in addition to Mycoplasma pneumoniae, Chlamydia pneumoniae, and Bacillus anthracis. Individuals should choose the right antibiotic for them depending on the pathogen. The main adverse reactions caused by clarithromycin include bad taste in the mouth, gastrointestinal reactions, and headache, while levofloxacin hydrochloride causes the main adverse reactions such as insomnia, nausea, headache, diarrhea, and constipation. Clarithromycin or levofloxacin hydrochloride is contraindicated in pregnant and lactating women, as well as in those who are allergic to the ingredients contained in the drug. Clarithromycin is also contraindicated in people with severe hepatic impairment, water-electrolyte disorders, and it is forbidden to combine Clarithromycin with astemizole, cisapride, pimozide, and so on. Individuals with unusual serious adverse reactions to medication should promptly inform a medical professional for disposition. Whether you use Clarithromycin or Levofloxacin Hydrochloride, you should follow the principle of scientific and reasonable use of medication, and follow the doctor’s instructions.