The difference between the six flavors of dihuang pill and the heavenly king’s heart pill is that the drug composition is different, the efficacy is different, the main treatment disease is different, the adverse reaction is different. 1. The composition of different drugs: six flavors of rhizome pill ingredients are wine cornelian cherry, poria, zejiao, ripened rhizome, yam, mudanpi. 2. The efficacy is different: nourishing Yin and tonifying the kidney is the efficacy of the Six-flavored Di Huang Pill. Nourishing the heart and tranquilizing the mind, nourishing yin and nourishing blood (nourishing the blood in the body) are the effects of Tianwang Xinzhu Pill. 3. Different treatments: Six-flavored Di Huang Pill is used for the treatment of bone vaporization and tidal fever (a burst of heat, feeling that the heat is coming from inside the bone to the outside) (the heat evaporates out of the bone), dizziness and tinnitus, lumbar and knee soreness and weakness (feeling of soreness and weakness of the lumbar and knee), night sweating (abnormal sweating after going to sleep, and stopping the sweating after waking up), and spermatorrhea. Tianwang Xinzhu Pill is used for insomnia and dreaminess caused by insufficiency of heart yin, forgetfulness, palpitation (rapid heartbeat, often accompanied by panic), and dry stools. 4. Adverse reactions are different: Tianwang tonic pill adverse reactions have gastrointestinal discomfort. Liuwei Di Huang Wan has diarrhea, abdominal pain, abdominal distension, nausea, vomiting, gastrointestinal discomfort, loss of appetite, constipation, itching, rash, headache, palpitations, allergies and other adverse reactions. It is contraindicated for those who are allergic to Liufei Di Huang Wan or Tian Tian Zhen Xin Wan. It should be used by a doctor for evidence-based treatment.