Creatinine 159μmol/L is not serious if it is caused by physiological factors, such as strenuous exercise, eating a lot of meat, etc.; it is not serious if it is caused by pathologic factors, such as acute renal failure (e.g., diarrhea, urinary tract obstruction, etc.); it is more serious if it is caused by chronic renal failure. Elevated creatinine can be seen in physiological conditions such as strenuous exercise, eating a lot of meat, muscular athletes, etc., then it is not serious, pay attention to rest, eat a light diet, and regular review can be. If pathological factors such as acute renal failure, common causes such as diarrhea, urinary tract obstruction, etc., generally not serious, remove the cause, generally can return to normal. Elevated creatinine is generally more serious if it is caused by pathological conditions such as chronic renal failure, common causes such as glomerulonephritis, hypertensive renal damage, diabetic nephropathy, etc. Therefore, this kind of disease can not be cured and may progressively develop, even to uremia stage, requiring renal replacement therapy. It is recommended to go to regular hospitals to find out the cause of elevated creatinine and standardize the treatment under the guidance of physicians.