Pain in the popliteal fossa can be treated with the following methods: first, conservative treatment, local use of ultrashort wave therapy, microwave therapy, to promote the absorption of inflammation and relieve pain symptoms, but also external application of Furtalin ointment, compound Nanxing pain relief cream to promote the relief of pain symptoms. Patients can take oral non-steroidal anti-inflammatory drugs such as loxoprofen sodium to relieve pain. Weight-bearing and activities of the knee joint should be limited, and repeated flexion and extension of the knee joint should be avoided, which can reduce the bad irritation and be beneficial to the relief of pain symptoms. Second, surgical treatment, if serious diseases of the knee joint cause pain in the popliteal fossa, you need to consider knee arthroscopic surgery to improve the lesions of the structures within the knee joint in order to relieve the pain in the popliteal fossa. If there is a cyst, it should be removed at the same time. The popliteal fossa pain symptoms will gradually be relieved by the above methods of treatment.