The obvious soreness when pressing on the pisiform area may be related to overwork, local trauma, tenosynovitis, arthritis, carpal tunnel syndrome and other factors. 1. Excessive fatigue: seen in the long time for hand grasping activities of the crowd, such as in the holding instruments, tools for excessive labor, will cause excessive fatigue at the intergluteal muscles, the local lactic acid accumulation, resulting in obvious soreness, generally can be relieved after rest. 2. Local trauma: If the skin or muscle of the piriformis is damaged due to extrusion, twisting and other traumatic injuries, it will also cause obvious local pain. 3. Tenosynovitis: If the thumb is overused for a long time, it may cause aseptic inflammation of the tendon and tendon sheath on the palm side of the thumb, resulting in soreness and pain. 4. Arthritis: If there is osteoarthritis of the thumb metacarpophalangeal joint, gouty arthritis, rheumatoid arthritis and other diseases, there will also be obvious soreness when pressing on the big fish joint near the joint. 5. Carpal tunnel syndrome: when the median nerve is compressed in the carpal tunnel, there will be pain, numbness and weakness in the lateral part of the palm, and there will also be the symptom of obvious soreness when pressing at the level of the big fish. There are other reasons for the obvious soreness when pressing on the pisiform area, if it is not relieved after resting, it is recommended that you should go to the hospital in time to complete the relevant examinations, clarify the cause of the disease and then follow the doctor’s instructions to carry out targeted treatment, so as to avoid delaying the condition.