Early syphilis treatment costs about 100 RMB/treatment, while treatment for advanced syphilis with complications costs about 500 RMB/treatment or more, with fluctuating costs depending on the region and the level of the hospital. Syphilis is one of the most common infectious diseases in the clinic, it is a chronic infectious disease caused by syphilis spirochete infection, the clinical manifestation is complex, it can invade all organs of the body, causing multiple organs with varying degrees of damage, which seriously threatens the life and health of the infected person. The cost of syphilis treatment includes not only the cost of medication, but also the cost of tests. For early syphilis: the diagnosis of syphilis needs to do the corresponding serum antigen antibody test, about 60 to 70 yuan, plus the cost of long-acting penicillin injection ranging from 20 to 30 yuan, a total of about 100 yuan / time. In advanced syphilis, because of more complications, such as neurosyphilis, cardiovascular syphilis, etc., the cost of treatment (including tests and examinations) will be significantly higher, about 500 yuan/times, and if the comorbidities are more complex and serious, the price is often more than that. To summarize, the price of syphilis treatment depends on which stage of syphilis and whether there are any complications, and the specific price is recommended to refer to the local hospital’s charges. If there is any discomfort, it is recommended to consult a doctor in time and follow the doctor’s instructions.