The clinical treatment of infants with buttock flooding requires different treatment options depending on the manifestation of the rash and the age. Infants usually have an irritation reaction due to local urine retention as a result of wearing unsuitable diapers, resulting in erythema and papules on the buttocks, and in severe cases, vesicles and oozing. If the infant is less than 1 week old, you can just apply a wet compress of 2% boric acid solution topically, and you need to stop using this diaper and replace it with a cotton cloth diaper for care. If the infant is older than 1 week of age, oral dexloratadine dry suspension can be given. If the infant is older than 2 weeks old, he or she can be treated with oral loratadine syrup.