A small amount of menstruation after taking progesterone is generally a normal phenomenon, but if the patient uses progesterone after the occurrence of more than vaginal bleeding or other abnormal symptoms, it must be dealt with in a timely manner. Progesterone belongs to the progesterone class of drugs, mainly used for the treatment of premenstrual abortion, habitual abortion, premenstrual tension syndrome, anovulatory dysmenorrhea, anovulatory amenorrhea, and estrogen used in conjunction with the treatment of menopausal syndrome. Patients taking it will have some effect on the hormone levels in the body, and some women may experience a small number of menstrual periods, but this is usually normal. Adverse effects such as breakthrough bleeding, vaginal spotting, weight gain or loss, and changes in the cervical squamous-column junction may occur with the use of progesterone. Since progesterone is a prescription medication, it needs to be used properly under medical supervision. It is contraindicated for those who are allergic to progesterone, those with unexplained vaginal bleeding, thrombophlebitis, vascular embolism, stroke or a history of the disease, and patients with breast and genital tumors. If patients use progesterone after the occurrence of vaginal bleeding or other abnormal symptoms, it is recommended to consult a doctor for examination and follow the doctor’s instructions to deal with the treatment.