Psoriasis, commonly known as psoriasis, is a chronic inflammatory skin disease. As we enter winter, along with the drop in temperature, many people with psoriasis begin to have a relapse. Which is a more scientific approach to treating psoriasis? What misconceptions exist in the treatment at present? 1, why does the condition of psoriasis patients aggravate or relapse in winter? There are many factors, the simple point is that psoriasis occurs only in people with a specific genetic background in a specific environment, one without the other. Psoriasis is a latitudinal disease, with the lowest incidence at the equator. In Africa, psoriasis is basically invisible, and the further north you go, the higher the incidence. For example, in China, the incidence is lowest in Hainan, and it starts to be found in Guangdong. There are more people with the disease north of the Yangtze River, and less south of the Yangtze. This shows that psoriasis is related to cold, cold weather will catch a cold, it will trigger an infection; the skin becomes dry and itchy after being cold, the hand scratches and destroys the skin barrier, bacteria from the epidermis fall to the dermis, leading to activation of the immune system and inflammation. 2.What are the drugs for the treatment of psoriasis? There are currently two major ways to treat psoriasis, one is biological agents. However, they are not popularly used in domestic dermatology. It is mainly due to three reasons. First, we put forward the theory that psoriasis treatment should be skin-specific, not systemic. Second, the biological agents developed abroad are too expensive, and the people are under great pressure to pay out of pocket. Third, such drugs depend on the long-term efficacy, and there are safety issues. Many biological agents have just come out, and it will take a few years before we know whether there are serious side effects. Another category of drugs is topical drugs, such as keratin promoters and keratolytics, glucocorticoids, retinoids, vitamin D3 derivatives and calcium-regulated neuronidase inhibitors. 3.What are the misunderstandings of patients in psoriasis treatment at present? Patients are eager for success and prefer to take drugs and injections. There are three main reasons for this. Firstly, patients are too busy to put on ointment and prefer to take medicine and injections. Secondly, influenced by Chinese medicine, they think that psoriasis is a blood disease, it comes from the blood and its essence is in the blood, so to treat the blood, they must take pills and injections. Thirdly, the effect of topical drugs is slow and the short-term effect cannot be seen, unlike the immediate effect of medication and injection. 4.Patients have other underlying diseases, what do I need to pay attention to with medication? If the treatment is for the skin, there is nothing to pay attention to. For example, many people like to take oral retinoids, which can increase hyperlipidemia and aggravate hypertension and heart disease. If the use of hormonal drugs, either long-term topical or oral will lead to increased blood sugar, etc. Psoriasis patients who suffer from underlying diseases themselves should emphasize the treatment of the skin. 5.Can psoriasis patients prepare for pregnancy during the use of medication? Pregnant women or those preparing for pregnancy have no problem with topical medication, but if it is an internal medication, all systematic treatments for psoriasis should be contraceptive, and almost all oral medications for psoriasis have adverse effects on the fetus.