Temporary exacerbation of acne, commonly known as breakouts, may occur during the first 1-2 weeks of taking isotretinoin, and usually subsides gradually around the 2nd-4th weeks after the medication is administered. Isotretinoin is mainly used to treat severe refractory nodular acne, and it has an anti-keratinizing effect on acne. If acne breakouts occur after taking isotretinoin, those with less severe symptoms can continue to use the medication and the symptoms will gradually reduce and disappear. If the symptoms are more serious, the dosage can be reduced or suspended and observed for a period of time first, and most of them can gradually recover in about 1-2 weeks. Isotretinoin generally has obvious adverse reactions after taking the drug, such as itchy, dry skin, rash and other symptoms, and some may develop osteoporosis and gastrointestinal symptoms. Therefore, patients generally consider isotretinoin only when other conventional treatments are ineffective. At the same time, spicy and stimulating, cold and greasy food should be avoided, and a light and easy-to-digest diet should be the mainstay. When taking isotretinoin, patients should avoid pregnancy to prevent fetal malformations. The medication must be administered under the guidance of a medical professional, and should not be used blindly on your own.