Cranial defects in some people are children, children have small cranial defects, and may form thin bone fragments in the later stages, which is a chronic process. The degree of localization in the later stage depends on the individual’s physique, and some children may grow well if the defect is observed for a long period of time and is small in size. However, there is no systematic evidence for large defects. So even in developing children, cranial defects may not grow well on their own. Patients should plan for the worst and not take any chances. Patients with cranial defects often have a heavy burden of thoughts such as insecurity and can cause syndromes such as headaches, dizziness, and fear of vibration. The longer the cranial defect, the higher the incidence of cranial defect syndrome and secondary brain damage. So for safety reasons, cranial bone repair is necessary. Of course, cranial bone repair material is also very important. Cranial bone repair material is usually chosen peek, the material has better histocompatibility. It is more comfortable and the thickness is strengthened. It is similar to human skull. Especially for pediatric patients, it can better adapt to the growth and development of the human autogenous cranium. And it will have a lower rate of infection and rejection. Importantly, PEEK is a material that can be three-dimensionally plasticized, and it can be three-dimensionally customized according to different patients’ conditions, which can really restore the physiological structure of the skull perfectly. Currently, we are using PEEK material to do cranial bone repair surgery, and we have achieved good clinical results, recognized and praised by patients. It is recommended that patients with cranial defects go to regular hospitals as soon as possible to take the appropriate materials to repair the skull, and get well soon.