Cranial defects above 3*3cm need to be repaired as soon as possible, and the choice of repair material is important to many patients. We can see that titanium mesh is now common, and some people after the use of titanium mesh will have a reaction, dizziness and headache phenomenon, and even after a long time the titanium mesh will be exposed, very scary. When this happens, the patient will have to have the mesh removed again, have new material put in, undergo another craniotomy, and the family will have to wait outside the operating room again in fear, and the cost of the surgery will be a large sum of money again. This is not worth the cost, so patients are advised to choose the best material for their skull repair, in order to avoid the worst situation after the surgery. The peek material is currently a better material to repair the skull, although the price is a little more expensive, but the peek material has been through a lot of clinical testing, and has received good postoperative feedback, many people do not appear after the use of discomfort, feel very comfortable, like their own bones. The peek material has perfect shaping ability, the use of advanced 3D printing technology to accurately replicate the human body’s defective skull, and radiation can be transmitted, will not affect the postoperative examination, high temperature resistance, corrosion resistance, strong resistance to impact, is the cranial repair patients to choose a better material with the advancement of medical science, there are gradually more cranial repair materials for use. Plexiglass, light apatite and calcium phosphate bone cement materials that were once used in clinical practice have been gradually withdrawn from the medical stage due to their poor clinical effects. Nowadays, the commonly used cranial bone repair material is titanium mesh, which is also a high-quality material that has been used for a long time with good results. However, the metal properties of titanium mesh often bring consequences such as sensitivity to hot and cold reactions and CT imaging errors to patients. Under the efforts of medical researchers, a new type of cranial bone repair material has been applied to clinical applications, that is, PEEK material. The scientific name of this material is polyether ether ketone, which is a kind of polymer biomaterials, in terms of elasticity, heat conduction, hardness, stability and other aspects of the human cranium is extremely close to the use of three-dimensional molding of the PEEK bone plate, can be a perfect fit with the skull structure, do not have to worry about the accuracy and aesthetics of the problem. Numerous clinical cases have shown that PEEK cranial bone repair materials have not been found to bring discomfort, so that PEEK is the current better choice for cranial bone repair.