Transaminases are most familiar to patients with liver disease. Clinically, there are two types of transaminases, glutamic aminotransferase (AST) and alanine aminotransferase (ALT). Aminotransferases are essential catalysts in the normal functioning of the liver, a chemical factory, and a barometer of the liver, and hepatocytes are the main living place of aminotransferases. When liver cells are damaged by inflammation, poisoning or necrosis, transaminases will be released into the bloodstream, causing an increase in serum transaminases. This means that when we find an increase in transaminases in our liver function test, it means we have liver disease. The transaminases in liver disease are higher than normal, can we lower them to normal with enzyme-lowering drugs? Does the reduction of transaminases to normal values by enzyme-lowering drugs mean that the liver disease is cured? The answer is no, and the reason is very simple. The use of enzyme-lowering drugs can quickly bring transaminases back to normal, but they will rebound as soon as the drugs are stopped. This is not a real cure, but a temporary suppression, after stopping the drug may rebound more powerful, the damage to the human body may also be will be greater. It will also have a negative impact on the subsequent treatment of liver disease. The use of enzyme-lowering drugs must be cautious. The right treatment for liver disease should also be taken: 1. antiviral therapy, through the viral hepatitis virus suppression, to achieve the effect of transaminase recovery. 2. reduce liver inflammation drugs, such as glycyrrhizin class, it is not enzyme-lowering drugs, but non-specific anti-inflammatory drugs. It can control the inflammation and play the effect of transaminase gradually decrease. Thus, for the treatment of liver disease, the use of enzyme-lowering drugs to bring transaminases down to normal values is not a cure for liver disease. As long as the regular antiviral treatment, anti-inflammatory treatment and anti-liver fibrosis treatment, so that the transaminases return to normal values, only then can we be sure that the liver disease is really cured.