Ulcers at the end of the ileum are not malignant diseases, they are benign lesions, including Crohn’s disease, intestinal tuberculosis, leukoencephalopathy and so on. 1. Crohn’s disease: Crohn’s disease can show pathological changes from the oral cavity to the anus, and enteroscopy can find ulcers at the end of the ileum, and the diagnosis is mainly based on pathological tests, which is often difficult. 2. Intestinal tuberculosis: intestinal tuberculosis can also be manifested as ulcers at the end of the ileum, which requires regular, long-term, adequate dosage and course of anti-tuberculosis drugs, such as isoniazid, rifampicin, ethambutol, etc., for treatment. 3. Leukoaraiosis: Leukoaraiosis is an autoimmune disease, there are gastrointestinal leukoaraiosis, can have ileocecal ulcers. Need long-term under the guidance of the doctor for anti-immune treatment. Such as taking prednisone, colchicine and other drugs treatment. Although the terminal ileal ulcer is not a malignant lesion, it is a more serious disease in clinical practice, and it is recommended to consult the gastroenterology department of regular hospitals.