Prolonged use of Pimecrolimus Cream may lead to a decrease in skin resistance and susceptibility to infectious diseases such as boils and herpes simplex. Pimecrolimus cream is an immunosuppressive cream that can regulate local immune function and inhibit inflammatory reactions. It is commonly used in the treatment of atopic dermatitis, but also in the treatment of eczema, contact dermatitis, psoriasis and other skin diseases. Pimecrolimus cream is safe and can be used for a long time for chronic atopic dermatitis, chronic eczema and other diseases, but long-term use is recommended to use intermittent therapy, each course of treatment does not exceed one year. Since pimecrolimus cream belongs to the immunosuppressive class of drugs, long-term use of pimecrolimus cream may reduce the local immune function of the skin, poor resistance to microorganisms, the site of the use of the drug is prone to herpes simplex, boils or viral warts. Prolonged application over a large area of the entire body may cause the body’s immune function to decline, which may increase the risk of developing malignant tumors. Pimecrolimus Cream is a prescription medication and needs to be used under the supervision of a professional dermatologist as prescribed by the doctor.