The highest level of antibiotics is special grade antibiotics. Special grade antibiotics are the highest level of antibiotics, mainly used for the treatment of drug-resistant bacteria, before the use of special grade antibiotics should be perfect specimens sent to the examination, to clarify the infection of the pathogenic bacteria and drug sensitivity results. Special-grade antibiotics can only be prescribed by physicians with appropriate prescribing authority, and can only be used after consultation and consent by relevant experts with clinical experience in anti-infection. Special-grade antibiotics include fourth-generation cephalosporins, carbapenems, glycopeptides, antifungals, etc., such as cefepime, meropenem, vancomycin, amphotericin B and so on. Special grade antibiotics should not be abused as they can lead to an increase in drug-resistant bacteria and may lead to future druglessness and must be used only when indicated. Specialty grade antibiotics should be used with caution in some people with liver or kidney insufficiency, pregnancy, etc. Special grade antibiotics may cause damage to the liver and kidneys and need to be used under the supervision of a medical professional.