Dry skin around the mouth generally belongs to keratitis, lipitis, lack of lipid dermatitis, etc., need to address the cause of the disease, take the appropriate drugs, such as anti-infective drugs, anti-allergy drugs, etc., for treatment. 1. Keratitis: bacterial infection of keratitis, antibiotic treatment, such as mupirocin ointment, etc.; fungal infection of keratitis, antifungal treatment, such as clotrimazole cream, miconazole cream, etc.; viral infection caused by keratitis, the use of antiviral treatment, such as acyclovir ointment, etc.; anaphylactic keratitis, treatment with antihistamines, such as cloratadine. 2. Lipitis: mostly caused by bad habits such as lip biting and lip licking, which should be stopped. Tacrolimus or pimecrolimus ointment is commonly used for treatment. 3. lack of seborrheic dermatitis: dry lips on both sides of the obvious, can be used externally moisturizing agent treatment, such as urea cream, etc.; there is obvious itching, can be used externally glucocorticoid treatment, such as hydrocortisone cream, mometasone furoate ointment, etc.; itching symptoms of the serious, can also be taken orally antihistamines, such as chlortetracycline, cetirizine and so on. It is recommended that patients go to a regular hospital, clear the disease, under the guidance of the doctor’s reasonable use of medication, not blindly self-medication.