Calluses on the hands can choose to use topical medication or physical therapy. 1. medication, if there has been a callus, callus is not very thick, you can choose to apply salicylic acid phenol paste, can soften the callus, corrosion of keratin, so as to achieve a better removal effect. 2. Physical therapy, if the callus is relatively large, more obvious, drug treatment can not be relieved, you can carry out carbon dioxide fractional laser treatment, can be through the laser beam on the skin, to relieve the symptoms of skin tissue hyperplasia. Usually it is best not to often excessive friction hands, so as not to lead to the thickening of the stratum corneum, calluses, usually can also be more hot water soaking hands, do a good job of skin care.