There is no best and fastest treatment for pericardial effusion. Due to the large individual differences, the treatment program varies from person to person, mainly including general treatment, drug treatment and surgical treatment. 1. General treatment: The main purpose is to detect the patient’s blood pressure, respiration, heart rate and other basic vital signs in a timely manner, provide nutritional support in a timely manner, and adopt a high protein, easy-to-digest, low-salt diet according to the needs, and actively carry out causative treatment for the primary diseases that lead to pericardial effusion. 2. Pharmacological treatment: Due to the different etiology and volume of effusion, there is a big difference between individual patients, so the individualized medication should be standardized under the guidance of the doctor, commonly used drugs include aspirin, colchicine, etc. In the acute onset of the disease, glucocorticosteroids can be used according to the doctor’s instructions if necessary. 3. Surgical treatment: When the amount of fluid is large, pericardiocentesis and pericardial drainage are required, which is a percutaneous puncture with a puncture needle under ultrasound guidance to suction out or drain out the fluid in the pericardium, thus reducing the pressure in the pericardium and relieving the cardiac pressure blockage. Therefore, when pericardial effusion is clearly identified, the patient should seek medical treatment in time, and the doctor will take the appropriate treatment plan according to the condition, so as to avoid delaying the condition.