Heart valve replacement is usually painless because general anesthesia is used during heart valve surgery and measures such as pain pumps are taken for pain relief after the surgery. Heart valve surgery is usually performed under general anesthesia because currently the main surgical method used to replace heart valves is open-heart surgery, and because open-heart surgery is more damaging, general anesthesia is used during the surgery. The anesthetics of general anesthesia are mainly divided into three parts, including static anesthetics, muscle relaxants, and sedative painkillers, the coordinated use of the three drugs can ensure the smooth progress of the surgical process, and at the same time ensure the safety of the patients. Post-operative measures such as pain pumps and anticoagulants can also be taken to alleviate post-operative pain or complications. Replacement of heart valves should be performed in a specialized hospital, by a professional doctor, and follow the doctor’s instructions.