High-risk stage IIA (stage 2A) colon cancer may generally need chemotherapy for 8 times, but it should be combined with the patient’s own condition, and the specific should follow the doctor’s instruction. Patients with stage IIA colon cancer should be treated with surgery first. High-risk patients with postoperative vascular infiltration, nerve infiltration, insufficient safe distance of margins, less than 12 lymph nodes delivered for examination, positive margins or unknown condition, preoperative intestinal obstruction or perforation of the tumor site may generally need to undergo postoperative adjuvant chemotherapy for 8 times, but the exact number of times should be determined in the light of the patient’s tolerance. High-risk stage IIA patients should start adjuvant chemotherapy as soon as possible after surgery, usually about 3 weeks after surgery, should not be later than 2 months after surgery, the total duration of adjuvant chemotherapy is usually 6 months, usually 8 times, chemotherapy regimen is often used oxaliplatin + capecitabine and so on. However, the specific number of times depends on the patient’s tolerance, such as some patients with drug allergy or severe chemotherapy reaction, may have to adjust the treatment program in time. Patients with high-risk stage IIA colon cancer should go to the hospital in time to improve relevant examinations and undergo chemotherapy under the guidance of oncologists.