Depression does not necessarily affect life expectancy, with the severity of the disease, individual quality, the timely effectiveness of treatment and other factors, the specific situation varies from person to person. 1. Less likely to affect the situation: the condition is mild, self-injurious suicidal concepts and behaviors are mild or even no, the pre-morbid condition is good, with social support, timely and effective intervention of the depressed patients, the general prognosis is good, will not have a significant impact on life expectancy. 2. Situations with a higher likelihood of impact: Depression that is more severe, combined with significant self-injurious suicidal ideation and behavior, poorer underlying conditions (e.g., impulsivity and other personality traits, lack of social support, frequency of negative life events, etc.), and with a longer course of illness and inappropriate diagnosis and treatment generally has a poorer prognosis, and the patient’s lifespan may be affected by self-injurious, suicidal, or substance-abusive behaviors. In conclusion, as a life-threatening disease, depression must be diagnosed and treated in a timely manner in a specialized hospital in order to strive for a good prognosis. Do not blindly handle the problem on your own to avoid improper intervention and adverse consequences.