Glimepiride belongs to sulfonylurea hypoglycemic drugs, which can promote insulin secretion from pancreatic islet B cells and is mainly used for the treatment of type 2 diabetes mellitus. Glimepiride effect and efficacy: mainly used for type 2 diabetes mellitus that can not be controlled by diet control, physical exercise and weight loss, by promoting insulin secretion to reduce blood glucose. Glimepiride adverse reactions: nausea, vomiting, hypoglycemia, abnormal liver function, abnormal vision status and skin rash may occur during the use of the drug. Contraindications to Glimepiride: contraindicated in pregnancy and lactation, contraindicated in patients with type 1 diabetes mellitus, ketoacidosis and diabetic coma, contraindicated in severe hepatic and renal abnormalities, and contraindicated in those who are allergic to the product. Glimepiride precautions: should follow the doctor’s instructions to use the drug, pay attention to diet, exercise and time of use; avoid drinking alcohol during the use of the drug; use of the drug once the occurrence of obvious hypoglycemia, serious abnormalities of liver and kidney function, obvious gastrointestinal reaction and generalized rash, need to stop using the drug in time to seek medical observation. The above drugs should be used under the guidance of a doctor to avoid adverse effects.