Cirrhosis bilirubin 200 can not be reduced to consider the occurrence of liver failure, the treatment mode has drug therapy, artificial liver, liver transplantation and so on. 1. Drug treatment: patients with hepatitis B need to use drugs such as entecavir and other medications, and can also use hepatoprotective drugs, such as reduced glutathione, adenosylmethionine, etc.; patients with ascites can use diuretic drugs such as furosemide and spironolactone. 2. Artificial liver: it belongs to blood purification technology, mainly includes blood replacement and blood perfusion, etc., which can adsorb the excess bilirubin and buy time for liver transplantation. 3. Liver transplantation: For severe cirrhosis, liver transplantation can also be considered. In addition, other factors should be considered to cause bilirubin elevation, such as liver cancer, which can squeeze the bile ducts and prevent bile from being discharged, in which case partial hepatectomy, segmental hepatectomy, etc., as well as interventional therapy and localized ablation therapy can also be considered. Patients with cirrhosis who cannot lower their bilirubin by 200% are advised to go to the hospital and ask the doctor to make a judgment and formulate an individualized treatment plan.