The disease has been known by many names, including “allergic subseptic disease”, which has been used for a long time in China, but since 1987 it has been called adult sclerosis. The etiology of the disease is unknown. Clinical features include fever, arthralgia and/or arthritis, rash, myalgia, sore throat, enlarged lymph nodes, neutrophilia, and thrombocytosis, with systemic damage in severe cases. Because there are no specific diagnostic criteria, the diagnosis of adult Still’s disease is often considered only after excluding infections and tumors, making it clinically difficult to diagnose adult Still’s disease. In some patients, even if the diagnosis of adult Sclerosis is made, close follow-up during treatment is required to further exclude the development of infections and/or tumors. The disease affects men and women similarly and is scattered worldwide without geographical differences. Diagnosis: The presence of the following clinical manifestations and associated investigations should be suspected. (1) Fever is the most prominent symptom of the disease and appears earliest, with a typical fever pattern of peak fever. The typical fever pattern is peak fever. It usually occurs once a day. (2) The rash is common on the trunk and extremities, but can also be seen on the face as an orange-red macular rash or maculopapular rash, usually accompanied by fever, and is transient. (3) There is usually arthralgia and/or arthritis, with early oligoarthritis or polyarthritis developing. Myalgic symptoms are also common. (4) Peripheral blood leukocytes are significantly elevated, mainly neutrophils, and blood cultures are negative. (5) Serologic tests are negative for rheumatoid factor and antinuclear bodies in most patients. (6) Multiple antimicrobial treatments were ineffective, while glucocorticoids were effective.