Adult Still’s disease is a clinical syndrome of unknown etiology with prolonged intermittent fever, transient polymorphic rash, arthritis or arthralgia, sore throat, and systemic involvement such as increased peripheral blood leukocyte count and granulocyte count and impaired liver function. Since 1987, it has been called Adult onset Still’s disease (AOSD), or more precisely Adult onset Still’s disease (ASSD). The disease should be considered in clinical cases with the three main signs of fever, rash and arthritis/arthralgia, leukocytosis and neutrophilia, increased ESR, negative blood cultures, and the four main features of ineffective antibiotic therapy and effective hormones. Diagnostic points include: 1. prolonged recurrent fever (high fever, single peak per day) while generally in good condition, with no obvious signs of toxicity, and as normal after the fever subsides; 2. recurrent transient, polymorphic rash associated with fever; 3. arthritis/arthralgia, which may be accompanied by muscle aches and pains to the same extent as the fever peak; 4. sore throat, which appears with fever and subsides with fever; 5. enlarged liver and spleen lymph nodes and pulmonary, cardiac, renal, and plasma membrane Multi-organ damage, which may return to normal after treatment; 6. Significantly increased leukocytes and neutrophils, increased ESR and CRP, abnormally elevated serum ferritin levels, abnormal liver function, negative ANA and RF, infectious bone marrow picture, and negative blood and bone marrow cultures; 7. Multiple antibiotic treatments are ineffective while responding well to hormones; 8. Other diseases can be ruled out.