Defects in the skull can pose a great threat to life and health, so many patients pay more attention in choosing the hospital and specialist surgery for their operation. The skull is a very hard bone in the human body and plays a very important role. It protects the brain and head and face organs of the human body, while maintaining a normal and stable intracranial pressure to ensure that all life activities are carried out in an orderly manner. Therefore, if a cranial defect occurs, it will pose a great threat to life and health, and should be repaired in time. Some patients with cranial defects ask if cranial repair surgery is dangerous. In fact, in today’s medical environment, skull repair is a relatively routine procedure in neurosurgery, which is very safe and basically risk-free. However, it is very important to choose a good skull repair material to achieve good results. This is because if the material is not good, it may lead to rejection, subcutaneous fluid, chronic pain, many complications, etc. PEEK is a newly developed polymeric biomaterial that has been used for a shorter period of time than titanium mesh, but is many times more effective than titanium mesh in clinical practice. PEEK, which is a highly reproducible physiological structure of the skull, is popular with patients because it is comparable to autologous cranial bone in terms of tissue description, hardness, stability, and thermal insulation. Through the above skull repair has the risk of detailed introduction, I hope it will be helpful to you. It is recommended that patients go to regular hospitals early to choose repair materials comparable to autologous cranial bone, repair in time and restore health as early as possible.