Painful urination after insertion of urinary catheter may be caused by irritation of urinary catheter, injury of urinary tract, combined urinary tract infection, etc., which can be relieved by general treatment, medication (levofloxacin, etc.), catheter drainage and other pain relief. 1. Urinary catheter stimulation: due to the urethra for a long time will inevitably stimulate the urethral mucosa, resulting in mucosal edema exudate, thus the patient will have pain in urination, generally no special treatment, the pain will be relieved on its own after the dissipation of edema. 2. Urinary tract injury: when the catheter is inserted may cause urethral injury, after removal of urine stimulation injury, causing painful urination, usually need to re-insert the catheter to drain the urine, to reduce the stimulation of the injury site, to promote healing. 3. Combined urinary tract infection: catheter retention is easy to cause infection, patients will have pain in urination, can be under the guidance of the doctor, through the anti-infective drugs for treatment, such as levofloxacin, amoxicillin, cefaclor and so on. Patients with discomfort, need to inform the doctor in time to the relevant examination, take targeted treatment.