If the blood pressure is measured at 190/110 mmHg, the diagnosis is hypertension grade 3 (severe), which is the target of antihypertensive drugs. The commonly used antihypertensive drugs in clinic include diuretics, beta-blockers, calcium channel blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists and other drugs. 1. Diuretics: Diuretics include thiazides, such as hydrochlorothiazide; labeled diuretics, such as furosemide; potassium-preserving diuretics, such as spironolactone. 2. β-blocking drugs: commonly used drugs include propranolol, metoprolol and so on. These drugs can inhibit the central and peripheral renin-angiotensin-aldosterone system, inhibit myocardial contractility and slow down the heart rate and play a role in lowering blood pressure. 3. Calcium channel blockers: commonly used drugs include nifedipine, verapamil, diltiazem, etc., which can achieve antihypertensive effect by dilating blood vessels, improving vascular endothelial function, slowing down heart rate, inhibiting myocardial contraction and atrioventricular conduction. 4. Angiotensin-converting enzyme inhibitors: commonly used drugs include captopril and enalapril. Through vasodilation and degradation of bradykinin, it promotes the release of prostaglandins to dilate blood vessels and lower blood pressure. 5. Angiotensin II receptor antagonist and other drugs: commonly used drugs are chlorosartan, valsartan and so on. The angiotensin II receptor subtype AT1 has a selective blocking effect, which makes the peripheral vascular resistance decrease, and the blood pressure decreases. When the blood pressure is measured as 190/110mmHg, the patient should actively cooperate with the doctor’s treatment, do not self-medication, so as not to delay the condition or adverse reactions.