It is possible to remove early adenocarcinoma in situ from the cervix by cold knife conization. After anesthesia is given to the patient, cold knife conotomy is performed on the cervix under the cold knife condition, and the tissue cut off is conical in shape, and the pathological examination of the tissue can be used to judge whether there is any lesion on the edge of the cut as well as on the tip of the cut tissue, and compared with the Lipstick, since there is no electrothermal damage, it is possible to see whether the edge of the cut is clean or not. In earlier cases of adenocarcinoma in situ, conization has a better chance of removing the lesion cleanly. If the lesion has already metastasized and spread, the conization may not be able to remove the lesion completely, and the lesion may recur to a certain extent, requiring a second conization or other treatments. It is recommended to consult a doctor in time and standardize the diagnosis and treatment.