A pregnancy with a high hepatitis B virus load may be contagious to the fetus and requires early mother-to-child interruption. If a quantitative hepatitis B virus test is performed at the time of pregnancy and the result is a high viral load, it is generally considered to be highly contagious. Mother-to-child transmission is one of the most important ways to transmit hepatitis B. Therefore, the possibility of directly transmitting the hepatitis B virus to the fetus through pregnancy is high. Therefore, it is necessary to carry out blocking treatment as early as possible. On one hand, oral antiviral drugs, including Tenofovir, etc., can be started at 6-7 months of pregnancy; on the other hand, hepatitis B immunoglobulin and hepatitis B vaccine can be given to newborns as early as possible; the earlier the injection is given, the better the expected effect is; however, it is necessary to consult with the doctor, who will decide the time for the injection according to the condition of the newborns, and the doctor’s advice shall prevail.