Clinically there is no such thing as an antidepressant with the least side effects. Commonly used antidepressants are fluoxetine, sertraline, mirtazapine, etc., all of which have certain side effects. 1. Fluoxetine: a selective 5-hydroxytryptamine reuptake inhibitor, commonly used in the treatment of obsessive-compulsive disorder, anorexia nervosa and senile depression. Adverse reactions include fear of eating, anxiety, taste changes, cough, chest pain, etc. It is contraindicated in patients who are allergic to the product or taking monoamine oxidase inhibitors and hereditary fructose intolerance. 2. Sertraline: belongs to a selective specific 5-hydroxytryptamine reuptake inhibitor, commonly used in the treatment of obsessive-compulsive disorder and various types of depression, and its adverse reactions include nausea, diarrhea, constipation, dyspepsia, dry mouth, excessive sweating, sexual dysfunction. It is forbidden for those who are allergic to this product and patients with severe liver or kidney insufficiency. 3. Mirtazapine: a tetracyclic atypical antidepressant, commonly used in the treatment of various types of depression and depressive episodes. Adverse reactions include increased appetite, weight gain, drowsiness, upright hypotension, tremor, etc. It is contraindicated for patients who are allergic to the product or its ingredients, pregnant women, women under 18 years of age, and patients who have used MAOIs within two weeks. If patients experience any of the above adverse reactions, it is recommended that they visit a specialized hospital and receive symptomatic treatment under the guidance of a doctor, and it is not recommended that they use the drug on their own.