Gastric heavy heterozygous hyperplasia usually requires endoscopic surgery. Gastric severe heterozygous hyperplasia is a kind of abnormal healing formed by the gastric mucosa in the continuous damage and repair, and the patients may have epigastric pain, nausea and vomiting, diarrhea and other symptoms. Since gastric severe heterozygous hyperplasia is a pre-cancerous lesion, it is necessary to resect the lesion endoscopically without surgical operation. Patients with severe gastric heterozygous hyperplasia need to be reviewed after endoscopic surgery. In daily life, they should strengthen exercise to improve their immunity, as well as pay attention to diet, avoid overeating, and maintain a good state of mind. At the same time, they should eat more eggs, fish and other easily digestible food that can replenish protein, eat more vegetables and fruits, and don’t eat spicy and stimulating food. Patients should go to the hospital after examination under the guidance of the doctor reasonable treatment, do not blindly decide on their own, so as not to delay the condition.