Generally cholecystectomy bile reflux gastritis can achieve clinical cure, need to take general measures, medication, surgical treatment, but it is difficult to cure. Cholecystectomy bile reflux gastritis is considered to be caused by bile reflux after cholecystectomy. According to authoritative data, in general, this disease can be clinically cured after timely and standardized treatment, but because the occurrence of bile reflux gastritis is related to the history of surgery, physical state and other factors, so there is a high recurrence, so it is difficult to be completely cured. Usually, patients need to correct bad dietary habits, regular routine, and avoid spicy and stimulating food. Secondly, gastric mucosal protectants such as magnesium aluminum carbonate and bismuth potassium citrate, gastrointestinal stimulants such as mosapride and domperidone, and proton pump inhibitors such as omeprazole and rabeprazole should be applied according to medical advice. If drug treatment is ineffective, surgical treatment such as jejunoileal interposition and Billroth I should be considered. To summarize, patients with bile reflux gastritis need to go to the hospital in time, establish confidence in treatment, under the guidance of the doctor to carry out regular treatment, and follow up on time.