The three hepatitis B highs are the high hepatitis B virus DNA load, high hepatitis B surface antigen and high hepatitis B e antigen after human infection with hepatitis B virus.1. High viral DNA load: represents a large amount of hepatitis B virus in the blood and is highly infectious, but does not reflect the severity of the disease. Sometimes the hepatitis B virus DNA load is high, but liver function can remain normal, this is called hepatitis B virus carriers, generally do not need treatment, only as a source of infection and exist. If abnormal liver function is detected, antiviral treatment is required; 2. High hepatitis B surface antigen: indicates that the hepatitis B virus in the body is replicating, the higher the surface antigen, the more active the hepatitis B virus replication. In the major triple-positive population, the quantification of hepatitis B surface antigen is usually higher, and the quantification of hepatitis B surface antigen in the minor triple-positive population may be lower; 3. High hepatitis B e antigen: indicates that the patient has been infected with the hepatitis B virus, which is currently replicating actively and may be more infectious. In addition, the virus appears to be actively replicating in hepatitis B patients before the three highs appear, and not all hepatitis B carriers will have the three highs. When a patient with hepatitis B has abnormal liver function, antiviral therapy may be considered under the guidance of a physician.