Vascular perforation of a solid lung nodule is not necessarily cancerous, but it should be ruled out as such, depending mainly on the nature of the solid nodule. Vascular penetration in solid lung nodules is mainly due to blood flow through the nodule, which is medically known as hematogenous dissemination or hematogenous metastasis. The nature of solid lung nodules is categorized into infectious and non-infectious as follows: 1. Infectious pulmonary nodules: if the pulmonary nodules are caused by infectious diseases, there are blood vessels passing through them, which is called hematogenous dissemination. Diseases that can cause hematogenous dissemination include hematogenous tuberculosis, blood-borne staphylococcus aureus, and so on. 2. Non-infectious pulmonary nodules: if the solid nodular lesion is not caused by infection, and there are blood vessels passing through it, it suggests that the mass has the possibility of hematogenous metastasis, and malignant tumors should be highly suspected, and it is necessary to observe whether the boundary of the nodule is clear and whether the density is even, and to make a definitive diagnosis through further examination such as pathological puncture, enhanced CT, and examination of tumor markers. If the solid nodule belongs to the infectious disease causing, even if there is blood vessel penetration, it is not necessarily malignant tumor. If the solid nodule is the possibility of malignant tumor, relevant examination should be carried out in time, diagnosis should be confirmed and surgical treatment should be carried out as early as possible.